Dosage Forms
- Farmentin ES-643 powder for oral suspension, after reconstitution each measure (5ml) contains 600 mg amoxicillin and 42.9 mg Clavulanic acid (as potassium).
Drug Group
Antibiotic, Beta-lactam + Beta-lactamase inhibitor
Packaging
- Powder for 75 ml oral suspension.
Farmentin ES-643 is given by mouth in the treatment of bacterial infections of lower respiratory tract, otitis media, sinusitis, skin and skin structure infections, urinary tract infections, chancroid and gonorrhea
Farmentin ES-643 is an oral antibacterial combination consisting of the semisynthetic antibiotic amoxicillin and the β-lactamase inhibitor, clavulanate potassium (the potassium salt of clavulanic acid). Betalactam antibiotic that inhibits the biosynthesis of cell wall of bacteria. Clavulanic acid has a high affinity for and binds to certain betalactamases that generally inactivate amoxicillin. Farmentin ES-643 is active against H. influenzae, M. catarrhalis, S. aureus, E. coli, Klebsiella sp. and Entrobacter sp.
Farmentin ES-643 is not indicated in history of hypersensitivity to penicillins, cephalosporins, imipenem and betalactamase inhibitors. Farmentin ES-643 should be used with caution in patients with evidence of hepatic dysfunction and history of GI diseases especially antibiotic-associated colitis. In renal impairment, reduction in dosage or increase in dosing interval is recommended. The suspensions contain aspartame and should not be used by phenylketonurics. Farmentin ES-643 in patients with infectious mononucleosis should not be used.
Diarrhea, hepatitis, cholestatic jaundice, pseudomembranous colitis, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis and exfoliative dermatitis have been reported.
Farmentin ES-643 crosses the placenta. Use during pregnancy only if clearly needed. Small amounts of amoxicillin are distributed into breast milk. The use of Farmentin ES-643 may cause diarrhea, candidiasis or allergic response in the nursing infants.
Probenecid prolongs the half-life of amoxicillin. Amoxicillin may also interact with bacteriostatic antibacterials. Co-Amoxiclav may reduce the efficacy of oral contraceptives. Concomitant use of allopurinol and amoxicillin should be avoided. Increases in prothrombin time have been reported in patients taking Co-Amoxiclav concurrently with anticoagulants. False-positive urine glucose reactions may occur in non-enzymatic tests using cupric sulfate in penicillin therapy.
