Dosage Forms
- 12.5 mg and 6.25 mg tablets
Drug Group
Non-selective beta receptors antagonist and selective alpha receptors antagonist.
Packaging
- 10 tablets in one blister. 3 blisters in a box.
Carvedilol is used in the management of hypertension and angina pectoris, and as adjunct to standard therapy in symptomatic heart failure. It is also used to reduce mortality in patients with left ventricular dysfunction following myocardial infarction.
arvedilol is a non-cardioselective beta-blocker. It has vasodilating properties, which are attributed mainly to its blocking activity at alpha receptors.
Since carvedilol has beta-blocking activity, it should not be discontinued abruptly, particularly in patients with ischemic heart disease. At the first sign/symptom of liver dysfunction, perform laboratory testing. Carvedilol is contraindicated in patients with NYHA class IV decompensated cardiac failure, bronchial asthma or related bronchospastic conditions, 2nd or 3rd degree AV block, sick sinus syndrome, cardiogenic shock or severe bradycardia.
As for beta-blockers liver function abnormalities (reversible), acute renal failure & renal abnormalities.
Pregnancy category C. Adequate and well-controlled studies in humans have not been done. It is not known whether carvedilol is distributed into breast milk.
Interaction of carvedilol with strong inhibitors of CYP2D6 (such as quinidine, fluoxetine, paroxetine and propafenone) has not been studied, but these drugs would be expected to increase blood levels of the carvedilol.