Anti-Nephrotic and Anti-Prostatic drug
Tamsulosin
Tamsulosin

Dosage Forms:

  • 0.4 mg capsule

Drug Group

alpha 1 adrenoceptor blocking agent

Mechanism

Tamsulosin exhibits selectivity for alpha 1 receptors in the human prostate. At least three discrete alpha 1-adrenoceptor subtypes have been identified: alpha 1A, alpha 1B and alpha 1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha 1 -receptors in human prostate are of the alpha 1A subtype. Tamsulosin HCl capsules are not intended for use as an antihypertensive drug.

Indications

Tamsulosin HCl capsules are indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH). Tamsulosin HCl capsules are not indicated for the treatment of hypertension.

Dosage and Administration:

  • Tamsulosin HCl capsules 0.4 mg once daily is recommended as the dose for the treatment of the signs and symptoms of BPH. It should be administered approximately one-half hour following the same meal each day. Tamsulosin HCl capsules are not indicated for use in pediatric populations.

Precautions and Warnings

Carcinoma of the prostate and BPH cause many of the same symptoms. These two diseases frequently co-exist. Patients should be evaluated prior to the start of Tamsulosin HCl capsules therapy to rule out the presence of carcinoma of the prostate.

Side Effects

The followings are the clinical adverse reactions considered possibly: Headache, Infection, Asthenia, Back pain, Chest Pain, Dizziness, Somnolence, Insomnia, Libido Decreased, Rhinitis, Pharyngitis, Cough Increased, Sinusitis, Diarrhea, Nausea, Tooth Disorder, Abnormal Ejaculation, Amblyopia and Orthostatic hypotension.
Interactions: 

Tamsulosin HCl capsules should NOT be used in combination with other alpha-adrenergic blocking agents. Cimetidine changes Tamsulosin HCl clearance (26% decrease) and AUC (44% increase). Therefore, Tamsulosin HCl capsules should be used with caution in combination with Cimetidine, particularly at doses higher than 0.4 mg.

Pregnancy and Lactation

Pregnancy category B. Tamsulosin HCl capsules are not indicated for use in women.

Packaging

  • 10 tablets in one blister. 3 blisters in a box.