Fargesic
Fargesic
Dosage Forms:
- Fargesic capsule contains Acetaminophen: 325 mg, Caffeine: 40 mg and Ibuprofen: 200 mg.
Drug Group
Mechanism
Indications
Dosage and Administration:
- Because capsules contains 3 active ingredients dosage should be adjusted according to this three active. In treatment of mild to moderate pains one capsule every 8 hours should be used.
Precautions and Warnings
Side Effects
Interactions: The risk of acetaminophen toxicity may be increased in patients receiving other potentially hepatotoxic drugs or drugs that induce liver microsomal enzymes. The absorption of acetaminophen may be accelerated by drugs such as metoclopramide. Excretion may be affected and plasma concentrations altered when given with probenecid. Colestyramine reduces the absorption of acetaminophen if given within 1 hour of Acetaminophen. Like theophylline caffeine undergoes extensive metabolism by hepatic microsomal cytochrome P450 isoenzyme CYP1A2, and is subject to numerous interactions with other drugs and substances which enhance or reduce its metabolic clearance. Interactions involving NSAIDs include enhancement of the effects of oral anticoagulants (especially by azapropazone and phenylbutazone) and increased plasma concentrations of lithium, methotrexate, and cardiac glycosides.
Pregnancy and Lactation
Packaging
- 10 capsules in one blister. 2 blisters in a box.
Meloxicam
Meloxicam
Dosage Forms:
- 7.5 mg and 15 mg tablets.
Drug Group
Mechanism
Indications
Dosage and Administration
Precautions and Warnings
Side Effects
Interactions: Meloxicam may reduce effects of antihypertensivites. Increased clearance with bile acid sequestrants e.g. colestyramine. Increased risk of renal failure with diuretics; may reduce natriuretic effects of furosemide and thiazides. May increase toxicity of methotrexate. Potentially fatal: May increase plasma concentrations and toxicity of lithium. Increased risk of severe GI effects with aspirin, warfarin.
Pregnancy and Lactation
Packaging:
- 10 tablets in one blister. 3 blisters in a box.
Diclofenac sodium
Diclofenac Sodium
Dosage Forms:
- 100 mg extended-release capsules
Drug Group
Mechanism
Indications
Dosage and Administration:
- For the relief of osteoarthritis, the recommended dosage is 100 mg once daily. For the relief of rheumatoid arthritis, the recommended dosage is 100 mg once daily. In the rare patient where Diclofenac Sodium-ER 100 mg/day is unsatisfactory, the dose may be increased to 100 mg twice daily. If the benefits outweigh the clinical risks of increased side effects. After observing the response to initial therapy with Diclofenac Sodium-ER, the dose and frequency should be adjusted to suit an individual patient’s needs.
Precautions and Warnings
Side Effects
Interactions: Aspirin: potential of increased adverse effects Methotrexate: enhance the toxicity of methotrexate Cyclosporine: increase cyclosporine’s nephrotoxicity ACE Inhibitors: diminish the antihypertensive effect of ACE inhibitors. Furosemide, Thiazide and Thiazide-like Diuretics: Diclofenac -XR can reduce the natriuretic effect of furosemide and thiazides. Lithium: NSAIDs have produced an elevation of plasma lithium levels and a reduction in renal lithium clearance. Warfarin: The effects of warfarin and NSAIDs on GI bleeding are synergistic, such that users of both drugs together have a risk of serious GI bleeding higher than users of either drug alone.
Pregnancy and Lactation
Packaging:
- 10 capsules in one blister. 3 blisters in a box.